How Cxbladder Works

Research from Pacific Edge shows that messenger RNA (mRNA) levels of specific biomarkers are present at different levels in urine samples from patients who have urothelial cancer than in patients who don’t.

Cxbladder tests harness this research by measuring the gene expression of the biomarkers present in a sample of the patient's urine. The relative levels of gene expression allows us to predict a person's likelihood of having urothelial cancer.

What Biomarkers Does Cxbladder Analyze?

Cxbladder tests for five mRNA signatures in a patient's urine:

• MDK: Blood vessel growth and cell migration. Principally involved in cell proliferation, migration and angiogenesis in cancer cells.
• HOXA13: Cell differentiation. Principally involved in cell differentiation and the morphogenesis and differentiation of the genitourinary tracts.
• CDC2 (CDK1): Cell division. Cyclin dependent kinase. Essential to mitotic cell cycle: cell proliferation.
• IGFBP5: Programmed cell death. Acts as an anti-apoptotic gene.
• CXCR2: Inflammation. Mediates neutrophil migration to sites of inflammation. Moderates non-malignant inflammation (reduces False Positives).

How Does Testing Work?

A small sample (5 ml) of mid-stream urine is required for the test. Once collected using our provided system and sent to our laboratory, the sample undergoes a precise set of processes to extract and purify the mRNA present.

In the Cxbladder test, each of the five biomarkers of interest is quantified by a different probe, and the relationship between the individual biomarkers is determined with a mathematical equation. The calculated outcome provides a measure of the probability of the presence of urothelial carcinoma (UC).

What Makes Cxbladder So Accurate?

Cxbladder calculates probability objectively, without relying on people to count cells manually, so the results of this urine mRNA gene expression test are reliable.

With high Negative Predictive Value (NPV) and high Sensitivity, tests in the Cxbladder suite are optimized for the reliable rule out of urothelial cancer.

The Cxbladder Suite Gives You Greater Confidence

The Cxbladder suite empowers you to streamline practice workflow, so you can focus your time and clinical resources on those that need it the most, while sparing low risk patients the discomfort, anxiety and risk of an invasive procedure. With non-invasive sampling and the option of in-home sample collection, delivers the best patient experience possible.

To learn more about the benefits of Cxbladder, contact one of our representatives today.
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Last Updated: 19 Dec 2024 05:08 pm