Cxbladder Detect Case Studies

The following case studies, with example data taken from the validation study,1 highlight the clinical usefulness of Cxbladder Detect.

Patient 1: 68 year-old with stage T1, low grade UC

Gender: Male

Age: 68

Tumor Stage: pT1

NMP22 Bladder Chek result: Negative

WHO 98 grade: Low

NMP22 ELISA result:Negative

WHO 73 grade: 2

Cytology result: Negative

Risk factors: Identified high risk occupation for 40 years, smoked for 4 years

Presentation: Consulted his general practitioner complaining of dysuria (painful urination) and presenting with macro-hematuria 

Summary: UC detected by Cxbladder and confirmed by flexible cystoscopy

Patient 2: 60 year-old with stage T1, high grade UC

Gender: Male

Age: 60

Tumor Stage: pT1

NMP22 Bladder Chek result: Negative

WHO 98 grade: High

NMP22 ELISA result: Positive

WHO 73 grade: 3

Cytology result: Negative

Risk factors: Identified high risk occupation for 40 years, smoked for 6 years

Presentation: Consulted his general practitioner after ongoing problems with macro-hematuria (1-3 episodes a day)

Summary: UC detected by Cxbladder and confirmed by flexible cystoscopy

Patient 3: 75 year-old with stage Ta, low grade UC

Gender: Male

Age: 75

Tumor Stage: pTa

NMP22 Bladder Chek result: Positive

WHO 98 grade: Low

NMP22 ELISA result: Positive

WHO 73 grade: 2

Cytology result: Negative

Risk factors: Identified high risk occupation for 40 years, smoked for 20 years

Presentation: Presented to his general practitioner after two days of macro-hematuria

Summary: UC detected by Cxbladder and confirmed by flexible cystoscopy

 

Cxbladder Triage Case Study

The following case study highlights the clinical usefulness of Cxbladder Triage. 

Patient 1: 68 year-old male presenting with chronic microhematuria

Gender: Male

Age: 66

History: Non-smoker, history of prostate cancer - radical prostatectomy in 2002

Cytology result: Negative

Risk factors: No history of occupational exposure

Presentation: Patient presented with chronic microhematuria. 

Summary: Patient had a full workup in 2010 that was negative and a cystoscopy one year prior to current evaluation.

The Low Probability Cxbladder Triage Result satisfied the patient and the urologist to forego a more extensive workup at this time.

The patient's medical management plan will include routine follow-up to closely monitor his microscopic hematuria. 

  • References

    1 O'Sullivan et al: A multigene urine test for the detection and stratification of bladder cancer in patients presenting with hematuria, J Urol 2012; 188: 741-747